Opportunity Information: Apply for PA 16 435
The Genomics of HIV/AIDS Drug Response and Co-Morbidities (R01) funding opportunity (PA-16-435) is a National Institutes of Health (NIH) research grant focused on using modern genomic tools to improve how HIV/AIDS is treated and how related health problems are prevented or managed. The core aim is to expand the use of high-throughput genotyping, genomic sequencing, and other genomic technologies in order to understand why people respond differently to HIV therapies and to other medications commonly used in people living with HIV. A central theme is generating genomic and related datasets that can be made broadly available to the research community, so that findings are not limited to a single study team but can be reused and built upon to accelerate progress across the field.
This opportunity emphasizes practical, patient-centered outcomes tied to precision medicine for HIV. That includes improving the efficacy of HIV/AIDS therapies (helping more patients achieve strong viral suppression and durable treatment success), improving safety (reducing toxicities and serious adverse drug reactions), and improving ease of use (supporting more tolerable and simpler regimens that promote long-term adherence). It also explicitly includes studying non-HIV drugs used in HIV/AIDS patients, reflecting the reality that many people living with HIV take medications for other conditions and may experience important drug-gene interactions, drug-drug interactions, or unique toxicity risks.
Another major objective is reducing HIV/AIDS-related comorbidities, coinfections, and complications through genomics-informed research. In practice, this can involve investigating genetic and genomic factors that influence vulnerability to, or outcomes from, conditions that commonly co-occur with HIV, as well as complications that arise from long-term infection, chronic inflammation, or extended exposure to therapy. By tying genomic variation to clinical outcomes, researchers can identify biomarkers, risk predictors, and mechanistic pathways that could eventually guide individualized treatment selection, monitoring strategies, or preventive interventions.
The award mechanism is an R01, meaning it supports full-scale, investigator-initiated research projects in health-related science. The opportunity is categorized as discretionary funding and falls under the health funding activity category, with CFDA number 93.172. While the listing notes an original closing date of 2020-05-07 and does not specify an award ceiling or expected number of awards in the provided text, the scientific purpose is clearly oriented toward producing high-value genomic resources and actionable insights into medication response and HIV-associated health burdens.
Eligibility is broad and includes many types of U.S. domestic applicants such as state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The announcement also highlights additional eligible applicant categories, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
International participation is allowed in a specific way. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) may apply, and non-domestic components of U.S. organizations are eligible to apply. However, foreign components as defined in the NIH Grants Policy Statement are not allowed under this announcement, which is an important boundary for structuring collaborations and determining where work can be formally scoped within the application.
Overall, this FOA targets genomics-driven research that can directly improve treatment decisions and health outcomes for people living with HIV by identifying genetic and genomic contributors to drug response, adverse events, and the broader set of comorbidities and complications that shape long-term quality of life. A distinguishing feature is the expectation that resulting genomic data resources be made widely available, reinforcing NIH priorities around data sharing, reproducibility, and maximizing the public health impact of funded research.Apply for PA 16 435
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Genomics of HIV/AIDS Drug Response and Co-Morbidities (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
- This funding opportunity was created on 2016-09-19.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the name and number of this funding opportunity?
The opportunity is titled Genomics of HIV/AIDS Drug Response and Co-Morbidities (R01) and is identified as PA-16-435.
Which agency offers this grant?
This is a National Institutes of Health (NIH) research grant opportunity.
What type of grant mechanism is used?
The award mechanism is an R01, which supports full-scale, investigator-initiated research projects in health-related science.
What is the main scientific purpose of the FOA?
The core purpose is to use modern genomic tools (such as high-throughput genotyping and genomic sequencing) to improve HIV/AIDS treatment and to better prevent or manage HIV-related health problems, especially by understanding why individuals respond differently to HIV therapies and other medications used by people living with HIV.
What kinds of genomic approaches does the FOA emphasize?
The FOA emphasizes expanded use of high-throughput genotyping, genomic sequencing, and other genomic technologies to link genetic and genomic variation with treatment outcomes, medication response, and health complications relevant to HIV/AIDS.
What patient-centered outcomes are emphasized?
The opportunity emphasizes practical outcomes aligned with precision medicine for HIV, including:
- Improved efficacy of HIV therapies (supporting strong viral suppression and durable treatment success)
- Improved safety (reducing toxicities and serious adverse drug reactions)
- Improved ease of use (supporting tolerable, simpler regimens that help long-term adherence)
Is the research limited to HIV antiretroviral therapies?
No. The FOA explicitly includes studying non-HIV drugs used in HIV/AIDS patients, reflecting that many people living with HIV take medications for other conditions and may face important drug-gene interactions, drug-drug interactions, or unique toxicity risks.
What does the FOA mean by HIV/AIDS-related comorbidities and complications?
The FOA focuses on reducing HIV/AIDS-related comorbidities, coinfections, and complications through genomics-informed research. This can include genetic and genomic factors that influence vulnerability to, or outcomes from, conditions that co-occur with HIV, as well as complications linked to long-term infection, chronic inflammation, or extended exposure to therapy.
What kinds of results or outputs is this FOA trying to generate?
A central theme is producing genomic and related datasets and connecting genomic variation to clinical outcomes so researchers can identify:
- Biomarkers
- Risk predictors
- Mechanistic pathways
The intent is that these outputs could eventually support more individualized treatment selection, monitoring strategies, and preventive interventions.
Is there an expectation around data sharing?
Yes. A distinguishing feature is the expectation that resulting genomic and related data resources be made broadly available to the research community, so findings can be reused and built upon to accelerate progress across the field.
What is the CFDA number and funding category listed?
The FOA lists CFDA 93.172 and is categorized as discretionary funding under the health funding activity category.
Does the provided information specify an award ceiling or the expected number of awards?
No. The provided text notes that it does not specify an award ceiling or the expected number of awards.
What was the closing date shown in the listing?
The listing notes an original closing date of 2020-05-07.
Who is eligible to apply (in general terms)?
Eligibility is broad and includes many types of applicants such as governments, educational institutions, nonprofit and for-profit organizations, small businesses, tribal entities, and certain federal and community-based organizations, as described in the FOA information provided.
Which U.S. government entities are listed as eligible?
Eligible U.S. government applicants listed include state, county, and local governments, as well as special district governments.
Are public and private higher education institutions eligible?
Yes. The eligible applicant types include public and state-controlled institutions of higher education and private institutions of higher education, including independent school districts.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes federally recognized Native American tribal governments and tribal organizations, including those other than federally recognized tribal governments.
Are nonprofits eligible, including those without 501(c)(3) status?
Yes. The FOA lists nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) as eligible applicant types.
Are for-profit organizations eligible?
Yes. The FOA includes for-profit organizations (other than small businesses) and also includes small businesses as eligible applicants.
Are public housing authorities eligible?
Yes. The eligible applicant types include public housing authorities/Indian housing authorities.
Are specific institution categories (like HBCUs or Hispanic-serving institutions) called out as eligible?
Yes. The FOA highlights additional eligible categories, including:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
Are U.S. territories or possessions eligible?
Yes. The announcement notes eligibility for U.S. territories or possessions.
Are faith-based or community-based organizations eligible?
Yes. The FOA includes faith-based or community-based organizations among the additional eligible applicant categories described.
Does the FOA allow international applicants?
Yes, in a specific way. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) may apply, and non-domestic components of U.S. organizations are eligible to apply.
Are foreign components allowed under this announcement?
No. The FOA states that foreign components (as defined in the NIH Grants Policy Statement) are not allowed under this announcement. This affects how collaborations and project work can be structured within the application.
What makes this FOA different from a typical single-team genomics study?
A defining feature is its emphasis on generating high-value genomic and related datasets intended to be broadly available, so results can extend beyond a single study team and accelerate progress across the wider research community.
How does this FOA connect to precision medicine in HIV?
The FOA is centered on genomics-driven research intended to directly support more individualized care for people living with HIV by identifying genetic and genomic contributors to treatment response, adverse events, and comorbidities that influence long-term outcomes and quality of life.
Browse more opportunities from the same category: Health
Next opportunity: Emerging Global Leader Award (K43)
Previous opportunity: Understanding and Addressing the Multi-level Influences on Uptake and Adherence to HIV Prevention Strategies Among Adolescent Girls and Young Women in Sub-Saharan Africa (R21)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 16 435
Applicants also applied for:
Applicants who have applied for this opportunity (PA 16 435) also looked into and applied for these:
| Funding Opportunity |
|---|
| Building Capacity of the Vietnamese Health System through provision of HIV/AIDS Clinical Care Mentorship and Technical Assistance under the President’s Emergency Plan for AIDS Relief Apply for CDC RFA GH13 136304CONT17 Funding Number: CDC RFA GH13 136304CONT17 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Support of Competitive Research (SCORE) Research Continuance Award (SC3) Apply for PAR 16 437 Funding Number: PAR 16 437 Agency: National Institutes of Health Category: Health Funding Amount: $75,000 |
| Selected Topics in Transfusion Medicine (R21) Apply for PAR 16 441 Funding Number: PAR 16 441 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Selected Topics in Transfusion Medicine (R01) Apply for PAR 16 440 Funding Number: PAR 16 440 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| “South African University-based Technical Assistance Aimed at Improving the quality of HIV/AIDS and related services in the Republic of South Africa under the United States Presidents Emergency Plan for AIDS Relief (PEPFAR)”. Apply for CDC RFA GH15 157403CONT17 Funding Number: CDC RFA GH15 157403CONT17 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| “Support the Strengthening and Utilization of Strategic Information Activities in the Republic of South Africa under the President’s Emergency Plan for AIDS Relief (PEPFAR).” Apply for CDC RFA GH15 157603CONT17 Funding Number: CDC RFA GH15 157603CONT17 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Changes in Cellular Architecture During Aging (R01) Apply for PA 16 442 Funding Number: PA 16 442 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Expanding Alcohol-Focused High-Priority Translational Research for HIV/AIDS (UH2/UH3) Apply for RFA AA 17 015 Funding Number: RFA AA 17 015 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Model Continuums of Care Initiative (MCCI) for Women and Girls at Risk and Living With HIV/AIDS and Harmful Alcohol and Associated Comorbidities Planning Cooperative Agreement (U34) Apply for RFA AA 17 013 Funding Number: RFA AA 17 013 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Public-Private Partnerships in PEPFAR Countries under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 153903CONT17 Funding Number: CDC RFA GH15 153903CONT17 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Cardiovascular and Pulmonary Research on E-Cigarettes (R01) Apply for RFA HL 17 021 Funding Number: RFA HL 17 021 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Enhancing Coordination, Integration and Dissemination of Evidence to Combat HIV/AIDS, TB, and Sexually Transmitted Infections (STI) in the Republic of Zambia under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 160203CONT17 Funding Number: CDC RFA GH15 160203CONT17 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Basic and Translational Research on Decision Making in Aging and Alzheimer's Disease (R21) Apply for PAR 16 449 Funding Number: PAR 16 449 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Basic and Translational Research on Decision Making in Aging and Alzheimer's Disease (R01) Apply for PAR 16 448 Funding Number: PAR 16 448 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Short-term Measurements of Physical Resilience as a Predictor of Healthspan in Mice (R01) Apply for RFA AG 17 040 Funding Number: RFA AG 17 040 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| NIAMS Clinical Trial Implementation Cooperative Agreement (U01) Apply for PAR 16 447 Funding Number: PAR 16 447 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAMS Clinical Trial Planning Grant (R34) Apply for PAR 16 446 Funding Number: PAR 16 446 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIH-CASIS Coordinated Microphysiological Systems Program for Translational Research in Space (UG3/UH3) Apply for RFA TR 16 019 Funding Number: RFA TR 16 019 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| International Bioethics Research Training Program (D43) Apply for PAR 16 454 Funding Number: PAR 16 454 Agency: National Institutes of Health Category: Health Funding Amount: $230,000 |
| Building Sustainable Capacity of the Ministry of Home Affairs to Address HIV and TB Prevention, Care and Treatment in Zambian Prisons and Respond to Child Sexual Abuse and Sexual Gender-Based Violence in the Republic of Zambia under the President’s Apply for CDC RFA GH15 160103CONT17 Funding Number: CDC RFA GH15 160103CONT17 Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 16 435", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.