Targeted Implementation Science to Achieve 90/90/90 Goals for HIV/AIDS Prevention and Treatment (R01) | PA 17 194

Opportunity Information: Apply for PA 17 194

Targeted Implementation Science to Achieve 90/90/90 Goals for HIV/AIDS Prevention and Treatment (R01) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number PA-17-194; CFDA 93.242) focused on implementation research that can measurably improve how HIV prevention and treatment services are delivered in real-world settings. The core purpose is not to test new drugs or basic mechanisms, but to study practical strategies for getting proven HIV interventions adopted, delivered well, and sustained within health systems and community programs. Projects are expected to be grounded in the realities of a specific community and built in active partnership with service providers, whether in the United States or internationally, so that the research directly addresses the local barriers that keep programs from reaching their goals.

The FOA is organized around the widely recognized 90/90/90 targets set by global HIV leadership. These targets define success as follows: first, 90 percent of all people living with HIV know their HIV status through effective testing and diagnosis efforts; second, 90 percent of those diagnosed are promptly linked to care and started on timely, effective antiretroviral therapy (ART); and third, 90 percent of those on ART achieve and maintain viral suppression, which maximizes health outcomes and reduces onward transmission. The emphasis is on targeted implementation science, meaning applicants should identify where along the testing-to-treatment-to-suppression pathway the biggest drop-offs occur in the selected population and then evaluate implementation approaches designed to close those gaps. In practice, this could include improving HIV testing uptake and repeat testing in high-risk groups, strengthening linkage and retention systems, reducing delays to ART initiation, supporting adherence and long-term retention, integrating services (for example, HIV care with substance use, mental health, maternal health, or STI services), or addressing structural and organizational issues like stigma, workforce constraints, clinic workflows, supply chains, and data systems that affect outcomes.

A defining feature of the announcement is the expectation that projects be designed in partnership with domestic and global service providers. That requirement signals that NIH is looking for studies embedded in functioning programs and clinics rather than purely academic exercises. Applicants are expected to tailor the research to the needs and context of the chosen community, which may include particular subpopulations, geographic areas, or service delivery platforms where 90/90/90 performance is lagging. The intended end result is actionable evidence about what implementation strategies work, for whom, and under what conditions, with the potential to scale successful approaches across similar settings.

Eligibility is broad and includes a wide range of governmental, academic, nonprofit, and private-sector organizations. Eligible applicants explicitly include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations (other than small businesses); small businesses; and other entities. The FOA also highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, and non-U.S. entities (foreign organizations) as well as regional organizations. This breadth supports the FOA goal of partnering with the organizations that actually deliver services and have direct access to the populations most affected.

In administrative terms, this is an NIH R01 research project grant mechanism under the health activity category. The FOA record lists an original closing date of 2018-01-24 and a creation date of 2017-03-03. An award ceiling is not specified in the provided source data, and the expected number of awards is also not specified in the excerpt. Overall, the opportunity is designed for applicants who can bring rigorous implementation research methods to the practical challenge of improving HIV program performance so that more people learn their status, start ART quickly, and achieve durable viral suppression at a population level.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Targeted Implementation Science to Achieve 90/90/90 Goals for HIV/AIDS Prevention and Treatment (R01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
• This funding opportunity was created on 2017-03-03.
• Applicants must submit their applications by 2018-01-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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