Opportunity Information: Apply for RFA HD 22 008
The Autism Centers of Excellence: Centers (P50 Clinical Trial Optional) funding opportunity (RFA-HD-22-008) is a National Institutes of Health (NIH) discretionary grant program led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in partnership with other NIH Institutes. It is designed to support Autism Centers of Excellence (ACE) "Centers" that bring together multiple research efforts under one highly coordinated, multi-disciplinary program. The overall idea is to fund a cohesive center-style structure where several related projects and shared core resources operate in a tightly integrated way, producing scientific synergy that would be difficult to achieve through separate, stand-alone grants.
This opportunity uses the P50 funding mechanism, which is specifically intended for specialized center programs rather than single-project awards. In practical terms, a P50 center typically combines multiple interlinked research projects with supporting "cores" (for example, shared clinical infrastructure, data management, biostatistics, imaging, biomarker labs, participant recruitment, community engagement, or administrative coordination). The FOA emphasizes integration and coordination across projects and cores, meaning applicants are expected to propose a unified program where the individual components reinforce each other, share resources efficiently, and collectively address major scientific questions in autism research. The "Clinical Trial Optional" designation indicates that the center may include clinical trials but does not require them; applicants can propose clinical trials if they fit the scientific plan, or focus on other forms of human or translational research without a trial component.
The funding activity is categorized within Environment, Health, Income Security and Social Services, and the listed CFDA numbers (93.113, 93.173, 93.242, 93.853, 93.865) reflect the NIH program authorities that may contribute to or align with this research support across different Institutes and topic areas. The award ceiling is listed as $1,500,000, which signals an upper bound on annual direct costs or total costs depending on the FOA's detailed budget rules (the source excerpt does not specify which). The opportunity was created on 2021-08-23, with an original closing date of 2021-11-09, indicating it was a time-limited request for applications rather than an always-open program announcement.
Eligibility in the provided source data is listed as "Small businesses," which suggests the opportunity, as captured in this record, allowed or targeted small business applicants. In NIH practice, P50 center grants are most commonly associated with research institutions like universities and medical centers, but the eligibility field here is what should be relied on for this summary. Applicants would be expected to demonstrate the capacity to run a complex, center-scale program, including strong leadership, experienced investigators from multiple disciplines, and the administrative and scientific infrastructure to coordinate several projects and shared cores under one governance structure.
A key contextual point is that this Centers FOA is paired with a companion funding opportunity for ACE Networks (RFA-HD-22-007), which uses the R01 mechanism. The relationship between the two is important: the P50 "Centers" program supports integrated, center-based research hubs with multiple coordinated components, while the R01 "Networks" FOA supports a different structure oriented around networked projects. Together, the two FOAs reflect a broader NIH strategy to advance autism research both through deep, multi-project center programs (P50) and through broader collaborative networks (R01).Apply for RFA HD 22 008
- The National Institutes of Health in the environment, health, income security and social services sector is offering a public funding opportunity titled "Autism Centers of Excellence: Centers (P50 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.173, 93.242, 93.853, 93.865.
- This funding opportunity was created on 2021-08-23.
- Applicants must submit their applications by 2021-11-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
- Eligible applicants include: Small businesses.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA HD 22 008) also looked into and applied for these:
| Funding Opportunity |
|---|
| Autism Centers of Excellence: Networks (R01 Clinical Trial Optional) Apply for RFA HD 22 007 Funding Number: RFA HD 22 007 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: $1,500,000 |
| Global Brain and Nervous System Disorders Research Across the Lifespan (R21 Clinical Trial Optional) Apply for PAR 21 319 Funding Number: PAR 21 319 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Global Brain and Nervous System Disorders Research Across the Lifespan (R01 Clinical Trials Optional) Apply for PAR 21 311 Funding Number: PAR 21 311 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Global Brain and Nervous System Disorders Research Across the Lifespan (R21 Clinical Trial Optional) Apply for PAR 22 098 Funding Number: PAR 22 098 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Global Brain and Nervous System Disorders Research Across the Lifespan (R01 Clinical Trials Optional) Apply for PAR 22 097 Funding Number: PAR 22 097 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed) Apply for PAR 23 171 Funding Number: PAR 23 171 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Implementation Research on Noncommunicable Disease Risk Factors among Low- and Middle-Income Country and Tribal Populations Living in City Environments (R01 Clinical Trial Optional) Apply for PAR 23 319 Funding Number: PAR 23 319 Agency: National Institutes of Health Category: Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
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