Opportunity Information: Apply for PAR 23 125
The NIH Avenir Award Program for Research on Substance Use Disorders and HIV (PAR-23-125) is a discretionary grant opportunity designed to invest in the "future" of HIV and substance use research by backing early stage investigators who want to pursue bold, highly innovative ideas. The program is aimed at projects that clearly sit at the intersection (the "nexus") of substance use or drug abuse and HIV/AIDS. Applicants are expected to make that connection explicit rather than treating substance use as a side topic. The overall emphasis is on creative, potentially high-impact research that aligns with NIH HIV/AIDS Research Priorities (as referenced in NOT-OD-15-137), with the longer-term goal of generating advances that matter for people who use substances and are living with or at risk for HIV.
The science scope is intentionally broad and can include both basic and clinical research, with clinical trials listed as optional under this DP2 mechanism. Competitive applications will typically propose unconventional or cutting-edge approaches that could change how the field understands, prevents, or treats HIV in substance-using populations. Examples of the kinds of impact the program is looking for include reducing HIV incidence, improving HIV therapies and outcomes, decreasing the burden of comorbid conditions that commonly accompany HIV and substance use (medical, psychiatric, and social), and contributing to the ultimate objective of ending the HIV epidemic. The opportunity is also framed around supporting investigators as individuals with transformative ideas, which is consistent with the Avenir concept of enabling promising researchers to establish a distinctive, innovative line of work early in their careers.
Eligibility spans a wide range of U.S.-based organizations and government entities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The notice also highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
At the same time, the program draws clear boundaries around foreign participation. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components, as NIH defines them in the NIH Grants Policy Statement, are allowed, which means a U.S. applicant may be able to include certain international elements in the research plan if they meet NIH requirements and are appropriately justified.
Administratively, this opportunity is run by the National Institutes of Health and falls under CFDA 93.279, within the health and education funding activity space. The funding instrument is a grant, and the listed original closing date is 2025-08-15. While the source data does not provide an award ceiling or expected number of awards, the defining features of the program are its focus on early stage investigators, its requirement for a well-justified substance use and HIV nexus, and its preference for highly innovative, potentially field-shaping research that can improve prevention, treatment, and long-term outcomes for substance-using populations affected by HIV.Apply for PAR 23 125
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Avenir Award Program for Research on Substance Use Disorders and HIV (DP2 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2023-03-10.
- Applicants must submit their applications by 2025-08-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Education, Health
Next opportunity: HEAL Initiative: Limited Competition: Data Coordinating Center for Completion of the Outcomes of Babies with Opioid Exposure (OBOE) Study (U24 Clinical Trial Not Allowed)
Previous opportunity: Cooperative Agreement for CESU-affiliated Partner with Great Lakes Northern Forests Cooperative Ecosystem Studies Unit
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 23 125
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 23 125) also looked into and applied for these:
| Funding Opportunity |
|---|
| Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit (U24 Clinical Trial Not Allowed) Apply for RFA CA 23 031 Funding Number: RFA CA 23 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Research With Activities Related to Diversity (ReWARD) (R01 Clinical Trial Optional) Apply for PAR 23 122 Funding Number: PAR 23 122 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Avant-Garde Program for HIV and Substance Use Disorder Research (DP1 Clinical Trial Optional) Apply for PAR 23 269 Funding Number: PAR 23 269 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Discovery and Development of Natural Products for Cancer Interception and Prevention (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA CA 23 028 Funding Number: RFA CA 23 028 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Impacts of climate change across the cancer control continuum (R01 Clinical Trial Optional) Apply for PAR 23 153 Funding Number: PAR 23 153 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Impacts of climate change across the cancer control continuum (R21 Clinical Trial Optional) Apply for PAR 23 152 Funding Number: PAR 23 152 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Request for Applications (RFA): Revision Applications to Support Research on Prevention and Cessation of Menthol Cigarette Use in Populations that Experience Health Disparities (R01, Clinical Trial Optional) Apply for RFA OD 23 015 Funding Number: RFA OD 23 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Liver Cancer Collaborative Projects with the Liver Cirrhosis Network (U01 Clinical Trial Optional) Apply for RFA CA 23 023 Funding Number: RFA CA 23 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Implementation Science for Cancer Control in People Living with HIV in Low- and Middle-Income Countries (U01 Clinical Trial Optional) Apply for RFA CA 23 033 Funding Number: RFA CA 23 033 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Understanding Persistent Oral Human Papillomavirus and Human Immunodeficiency Virus Co-infection and Its Role with Oropharyngeal Cancer Induction (R01 Clinical Trial Not Allowed) Apply for RFA DE 24 001 Funding Number: RFA DE 24 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Basic Experimental Studies with Humans (BESH) Required) Apply for PAR 23 158 Funding Number: PAR 23 158 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional) Apply for PAR 23 157 Funding Number: PAR 23 157 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Understanding Expectancies in Cancer Symptom Management (R01 Clinical Trial Required) Apply for PAR 23 155 Funding Number: PAR 23 155 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanistic Studies to Investigate the Interrelationship Between Sleep and/or Circadian Rhythms and Substance Use Disorders (R01 Clinical Trials Not Allowed) Apply for RFA DA 24 020 Funding Number: RFA DA 24 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R41/R42 Clinical Trial Optional) Apply for RFA DA 24 038 Funding Number: RFA DA 24 038 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Mechanistic Studies to Investigate the Interrelationship Between Sleep and/or Circadian Rhythms and Substance Use Disorders (R01 Basic Experimental Studies with Humans Required) Apply for RFA DA 24 021 Funding Number: RFA DA 24 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required) Apply for PAR 23 170 Funding Number: PAR 23 170 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Ending the HIV Epidemic: Resource Center to Engage Justice-Involved Populations (U24 Clinical Trial Optional) Apply for RFA DA 24 022 Funding Number: RFA DA 24 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Ending the HIV Epidemic: Focus on Justice Populations with SUD (R61/R33 Clinical Trial Required) Apply for RFA DA 24 015 Funding Number: RFA DA 24 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Ending the HIV Epidemic: Focus on Justice Populations with SUD-Data Coordination and Dissemination Center (UM1 Clinical Trial Optional) Apply for RFA DA 24 023 Funding Number: RFA DA 24 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 23 125", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.