Opportunity Information: Apply for PAR 22 249
The Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54 Clinical Trial Optional) opportunity (PAR-22-249) is a National Institutes of Health (NIH) cooperative agreement designed to build durable, long-term partnerships between two key types of institutions: (1) NCI-designated Cancer Centers (CCs) and (2) institutions serving underserved health disparity populations and underrepresented students (ISUPSs). The central idea is that sustained, mutually beneficial collaborations can strengthen the national cancer research enterprise while directly addressing persistent gaps in cancer outcomes, research participation, training, and community benefit for populations that experience disproportionate cancer burden. Because this is a cooperative agreement, recipients should expect an active partnership model with NIH involvement rather than a hands-off grant structure.
The program focuses on advancing cancer health equity by linking research capacity-building, education and workforce development, and community-facing activities into one coordinated partnership. CPACHE is meant to help institutions jointly tackle challenges in cancer research and cancer disparities research, expand education and outreach efforts, and translate those efforts into measurable improvements for underserved communities around the partner institutions. While clinical trials are optional under this U54 mechanism, the broader emphasis is on comprehensive collaboration that can support research projects and training pipelines aligned with cancer health disparities priorities.
Applicants are expected to work together across the partnership to accomplish four major goals. First, the partnership should increase cancer research and cancer research education capacity at the ISUPSs, which typically includes strengthening infrastructure, mentorship, curricula, research experiences, and institutional support needed to conduct and sustain cancer-relevant research and training. Second, the program aims to increase the number of students and investigators from underrepresented populations who are engaged in cancer research, which generally implies building clear pathways into cancer careers, providing structured training and mentored research opportunities, and improving retention and advancement of trainees and early-stage investigators. Third, CPACHE seeks to improve the effectiveness of Cancer Centers in developing and sustaining robust cancer health disparities research programs, while also increasing the number of investigators and students actively conducting cancer health disparities research. In practice, this goal emphasizes strengthening the Cancer Center side of the partnership as well, so disparities research is not peripheral but integrated and sustainable. Fourth, partnerships are expected to develop and implement cancer-related activities that provide direct benefit to surrounding underserved communities, reinforcing that community impact and engagement are not add-ons but core deliverables.
Eligibility is broad and spans government entities, academic institutions, nonprofits, and certain for-profit entities, reflecting the program’s emphasis on multi-sector capacity and community connection. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The opportunity also explicitly highlights additional eligible applicant categories commonly associated with serving underrepresented populations and health disparity communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
At the same time, the opportunity places clear restrictions on foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply. Non-domestic components of U.S. organizations are also not eligible to apply, and foreign components as defined by the NIH Grants Policy Statement are not allowed. These limits signal that the partnership work, capacity building, and community benefit activities must be carried out within eligible U.S.-based institutional and community contexts.
Administratively, the funding instrument is a cooperative agreement under the NIH, categorized under education and health activities, and tied to CFDA numbers 93.393 through 93.399. The listed award ceiling is $2,000,000. The opportunity was created on 2022-10-26, and the original closing date shown is 2023-01-06. Overall, CPACHE is structured to move beyond short-term projects by investing in comprehensive, sustained partnerships that expand the cancer research workforce, strengthen institutional capacity where it has historically been limited, deepen cancer center engagement in disparities research, and deliver tangible cancer-related benefits to underserved communities.Apply for PAR 22 249
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.397, 93.398, 93.399.
- This funding opportunity was created on 2022-10-26.
- Applicants must submit their applications by 2023-01-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| Feasibility Studies to Build Collaborative Partnerships in Cancer Research (P20 Clinical Trial Not Allowed) Apply for PAR 22 239 Funding Number: PAR 22 239 Agency: National Institutes of Health Category: Education, Health Funding Amount: $375,000 |
| Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Liquid Biopsy Research Laboratories (U01 Clinical Trial Not Allowed) Apply for RFA CA 23 018 Funding Number: RFA CA 23 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Functional Validation and/or Characterization of Genes or Variants Implicated in Substance Use Disorders (R21/R33 Clinical Trial Not Allowed) Apply for PAR 23 041 Funding Number: PAR 23 041 Agency: National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit (U24 Clinical Trial Not Allowed) Apply for RFA CA 23 019 Funding Number: RFA CA 23 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Targeting Inflammasomes in Substance Abuse and HIV (R01 Clinical Trial Not Allowed) Apply for RFA DA 24 003 Funding Number: RFA DA 24 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Targeting Inflammasomes in Substance Abuse and HIV (R21 Clinical Trial Not Allowed) Apply for RFA DA 24 004 Funding Number: RFA DA 24 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Investigating the Effects of Addictive Substances on Brain Developmental Trajectories Using Innovative Scalable Methods for Quantification of Cell Identity, Lineage and Connectivity (R01 - Clinical Trial Not Allowed) Apply for RFA DA 23 036 Funding Number: RFA DA 23 036 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Transformative Educational Advancement and Mentoring Network (TEAM) (R25 Clinical Trial Not Allowed) Apply for RFA CA 23 013 Funding Number: RFA CA 23 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program (R01 Clinical Trial Optional) Apply for RFA DA 23 059 Funding Number: RFA DA 23 059 Agency: National Institutes of Health Category: Education, Health Funding Amount: $3,000,000 |
| HEAL Initiative - Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program: Leadership and Data Co-ordinating Center (U01 Clinical Trial Optional) Apply for RFA DA 23 060 Funding Number: RFA DA 23 060 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,500,000 |
| Exploratory studies to investigate mechanisms of HIV infection, replication, latency, and/or pathogenesis in the context of substance use disorders (R61/R33 - Clinical Trial Not Allowed) Apply for RFA DA 24 002 Funding Number: RFA DA 24 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| NCI Cancer Screening Research Network: ACCrual, Enrollment, and Screening Sites (ACCESS) Hub (UG1 Clinical Trial Required) Apply for RFA CA 23 020 Funding Number: RFA CA 23 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| NCI Cancer Screening Research Network: Statistics and Data Management Center (UG1 Clinical Trial Required) Apply for RFA CA 23 021 Funding Number: RFA CA 23 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Cancer Screening Research Network: Coordinating and Communication Center (UG1 Clinical Trial Required) Apply for RFA CA 23 022 Funding Number: RFA CA 23 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanistic links between diet, lipid metabolism, and tumor growth and progression (UH2 Clinical Trial Not Allowed) Apply for PAR 23 052 Funding Number: PAR 23 052 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Mechanistic links between diet, lipid metabolism, and tumor growth and progression (U01 Clinical Trial Not Allowed) Apply for PAR 23 051 Funding Number: PAR 23 051 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Innovative Biospecimen Science Technologies for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed) Apply for RFA CA 23 004 Funding Number: RFA CA 23 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed) Apply for RFA CA 23 003 Funding Number: RFA CA 23 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advanced Development and Validation of Emerging Biospecimen Science Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed) Apply for RFA CA 23 005 Funding Number: RFA CA 23 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P01 Clinical Trial Optional) Apply for RFA CA 23 009 Funding Number: RFA CA 23 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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