Opportunity Information: Apply for PAR 22 249
The Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54 Clinical Trial Optional) opportunity (PAR-22-249) is a National Institutes of Health (NIH) cooperative agreement designed to build durable, long-term partnerships between two key types of institutions: (1) NCI-designated Cancer Centers (CCs) and (2) institutions serving underserved health disparity populations and underrepresented students (ISUPSs). The central idea is that sustained, mutually beneficial collaborations can strengthen the national cancer research enterprise while directly addressing persistent gaps in cancer outcomes, research participation, training, and community benefit for populations that experience disproportionate cancer burden. Because this is a cooperative agreement, recipients should expect an active partnership model with NIH involvement rather than a hands-off grant structure.
The program focuses on advancing cancer health equity by linking research capacity-building, education and workforce development, and community-facing activities into one coordinated partnership. CPACHE is meant to help institutions jointly tackle challenges in cancer research and cancer disparities research, expand education and outreach efforts, and translate those efforts into measurable improvements for underserved communities around the partner institutions. While clinical trials are optional under this U54 mechanism, the broader emphasis is on comprehensive collaboration that can support research projects and training pipelines aligned with cancer health disparities priorities.
Applicants are expected to work together across the partnership to accomplish four major goals. First, the partnership should increase cancer research and cancer research education capacity at the ISUPSs, which typically includes strengthening infrastructure, mentorship, curricula, research experiences, and institutional support needed to conduct and sustain cancer-relevant research and training. Second, the program aims to increase the number of students and investigators from underrepresented populations who are engaged in cancer research, which generally implies building clear pathways into cancer careers, providing structured training and mentored research opportunities, and improving retention and advancement of trainees and early-stage investigators. Third, CPACHE seeks to improve the effectiveness of Cancer Centers in developing and sustaining robust cancer health disparities research programs, while also increasing the number of investigators and students actively conducting cancer health disparities research. In practice, this goal emphasizes strengthening the Cancer Center side of the partnership as well, so disparities research is not peripheral but integrated and sustainable. Fourth, partnerships are expected to develop and implement cancer-related activities that provide direct benefit to surrounding underserved communities, reinforcing that community impact and engagement are not add-ons but core deliverables.
Eligibility is broad and spans government entities, academic institutions, nonprofits, and certain for-profit entities, reflecting the program’s emphasis on multi-sector capacity and community connection. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The opportunity also explicitly highlights additional eligible applicant categories commonly associated with serving underrepresented populations and health disparity communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
At the same time, the opportunity places clear restrictions on foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply. Non-domestic components of U.S. organizations are also not eligible to apply, and foreign components as defined by the NIH Grants Policy Statement are not allowed. These limits signal that the partnership work, capacity building, and community benefit activities must be carried out within eligible U.S.-based institutional and community contexts.
Administratively, the funding instrument is a cooperative agreement under the NIH, categorized under education and health activities, and tied to CFDA numbers 93.393 through 93.399. The listed award ceiling is $2,000,000. The opportunity was created on 2022-10-26, and the original closing date shown is 2023-01-06. Overall, CPACHE is structured to move beyond short-term projects by investing in comprehensive, sustained partnerships that expand the cancer research workforce, strengthen institutional capacity where it has historically been limited, deepen cancer center engagement in disparities research, and deliver tangible cancer-related benefits to underserved communities.Apply for PAR 22 249
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.397, 93.398, 93.399.
- This funding opportunity was created on 2022-10-26.
- Applicants must submit their applications by 2023-01-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54 Clinical Trial Optional) - PAR-22-249
What is CPACHE (PAR-22-249)?
Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) is a National Institutes of Health (NIH) cooperative agreement opportunity designed to build durable, long-term partnerships focused on advancing cancer health equity. It emphasizes coordinated work across research capacity-building, education/workforce development, and community-facing cancer activities.
What type of funding mechanism is this?
This opportunity uses a U54 cooperative agreement mechanism. Unlike a more hands-off grant, a cooperative agreement typically involves an active partnership model with NIH involvement during the project.
Which NIH institute is associated with this program?
The program is described in terms of partnerships with NCI-designated Cancer Centers (CCs), indicating alignment with the National Cancer Institute (NCI) within NIH.
What is the central purpose of CPACHE?
The central idea is that sustained, mutually beneficial collaborations between NCI-designated Cancer Centers and institutions serving underserved health disparity populations and underrepresented students (ISUPSs) can strengthen the cancer research enterprise while addressing persistent gaps in cancer outcomes, research participation, training, and community benefit for disproportionately impacted populations.
Who are the required or key partners in a CPACHE partnership?
CPACHE is designed around partnerships between two key institution types: (1) NCI-designated Cancer Centers (CCs) and (2) institutions serving underserved health disparity populations and underrepresented students (ISUPSs).
What does ISUPS mean in this context?
ISUPS refers to institutions that serve underserved health disparity populations and underrepresented students. The opportunity frames these institutions as key partners for building cancer research and education capacity and strengthening training pathways.
Is a clinical trial required under this opportunity?
No. The mechanism is listed as “Clinical Trial Optional,” meaning clinical trials are not required as part of the U54, although they may be included if appropriate.
What kinds of activities does CPACHE support?
CPACHE emphasizes comprehensive collaboration that links cancer research capacity-building, education and workforce development, and community-facing activities into one coordinated partnership. The overall intent is to translate partnership efforts into measurable improvements for underserved communities around the partner institutions.
What are the major goals applicants are expected to accomplish?
Applicants are expected to work across the partnership to accomplish four major goals: (1) increase cancer research and cancer research education capacity at ISUPSs; (2) increase the number of underrepresented students and investigators engaged in cancer research; (3) improve Cancer Centers’ effectiveness in developing and sustaining robust cancer health disparities research programs and increase the number of investigators and students conducting cancer health disparities research; and (4) develop and implement cancer-related activities that provide direct benefit to surrounding underserved communities.
What does “increase capacity at ISUPSs” typically involve?
Based on the description, this typically includes strengthening infrastructure, mentorship, curricula, research experiences, and institutional support needed to conduct and sustain cancer-relevant research and training at ISUPSs.
How does CPACHE address workforce development and training?
The program aims to increase the number of students and investigators from underrepresented populations engaged in cancer research by building clear pathways into cancer careers, offering structured training and mentored research opportunities, and supporting retention and advancement of trainees and early-stage investigators.
How does CPACHE strengthen cancer health disparities research at Cancer Centers?
One of the stated goals is to improve the effectiveness of Cancer Centers in developing and sustaining robust cancer health disparities research programs, and to increase the number of investigators and students actively conducting cancer health disparities research so disparities research becomes integrated and sustainable rather than peripheral.
What is expected in terms of community benefit?
Partnerships are expected to develop and implement cancer-related activities that provide direct benefit to surrounding underserved communities. Community impact and engagement are presented as core deliverables, not optional add-ons.
Who can apply for CPACHE funding?
Eligibility is broad and includes many U.S.-based entity types such as state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and additional categories highlighted for serving underrepresented populations and health disparity communities.
Does the opportunity specifically call out certain institution types?
Yes. It explicitly highlights categories commonly associated with serving underrepresented populations and health disparity communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs).
Are faith-based or community-based organizations eligible?
Yes. The eligibility description explicitly includes faith-based or community-based organizations among the highlighted eligible applicant categories.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly included among the additional eligible applicant categories.
Are federal agencies eligible to apply?
The eligibility section includes “eligible federal agencies” among the explicitly highlighted applicant categories.
Can a for-profit organization apply?
Yes. The eligibility list includes for-profit organizations other than small businesses, and also separately includes small businesses.
Are foreign organizations eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply.
Can a U.S. organization include a non-U.S. (foreign) component in the project?
No. Non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
What does the foreign involvement restriction imply for project activities?
It signals that partnership work, capacity building, and community benefit activities must be carried out within eligible U.S.-based institutional and community contexts, without foreign components as defined by NIH policy.
What is the maximum award amount listed for this opportunity?
The listed award ceiling is $2,000,000.
How is this opportunity categorized?
It is described as a cooperative agreement under NIH and is categorized under education and health activities.
What CFDA numbers are associated with CPACHE?
The opportunity is tied to CFDA numbers 93.393 through 93.399.
When was this opportunity created and what closing date is shown?
The opportunity was created on 2022-10-26, and the original closing date shown is 2023-01-06.
What makes CPACHE different from a short-term project grant?
CPACHE is explicitly structured to move beyond short-term projects by investing in comprehensive, sustained partnerships that expand the cancer research workforce, strengthen institutional capacity where it has historically been limited, deepen cancer center engagement in disparities research, and deliver tangible cancer-related benefits to underserved communities.
What does “durable, long-term partnership” mean for applicants?
Based on the description, applicants should plan for sustained, mutually beneficial collaboration between the partner institutions, with coordinated efforts across research capacity, training pipelines, and community benefit activities rather than isolated or one-off initiatives.
Is CPACHE only about research?
No. While it supports research capacity-building and cancer disparities research, CPACHE also emphasizes education and workforce development and requires cancer-related activities that provide direct benefits to underserved communities near the partner institutions.
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