Opportunity Information: Apply for RFA NS 18 029
The BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs (eTeamBCP) funding opportunity (RFA-NS-18-029) is a National Institutes of Health cooperative agreement (U01) designed to push forward large-scale, circuit-level neuroscience by bringing tightly integrated teams together around a focused biological question. The program is aimed at exploratory research that combines experimental innovation with rigorous analytics and theory, with the explicit goal of improving how scientists record from, perturb, and interpret activity across distributed neural circuits spanning multiple brain regions. Clinical trials are not allowed under this FOA, keeping the emphasis on fundamental circuit mechanisms rather than interventional studies in patients.
At the core of this opportunity is the expectation that applicants will study how dynamic patterns of neural activity actually contribute to a defined behavioral function or neural system. Competitive projects are expected to move beyond static descriptions of anatomy or average activity and instead test causal and computational ideas about circuit function. The FOA highlights a systems approach: investigators should systematically control stimuli and/or behavior while simultaneously recording and/or manipulating relevant neural activity patterns, then measure the resulting changes in behavior and/or perception. In practice, this points to experiments that link precisely designed tasks or ethologically relevant paradigms with advanced recording (for example, large-scale electrophysiology or imaging) and targeted manipulation (for example, opto- or chemogenetic perturbations, patterned stimulation, or other emerging tools) to reveal how circuits operate in real time.
A major theme is rich, multilevel circuit characterization. Applications are expected to incorporate detailed information about cell types, circuit connectivity, and circuit functionality, rather than treating the nervous system as a black box. This means proposals should be built to connect neural dynamics to the underlying biological substrate: which cell classes are involved, how they are wired, how information flows across regions, and how these features map onto computations that drive behavior. The FOA also places special weight on sophisticated analysis of complex behavior, including behaviors that are naturalistic or ethologically relevant, and on analytical strategies capable of handling high-dimensional neural and behavioral data. In other words, it is not enough to collect large datasets; teams are expected to demonstrate credible plans for extracting interpretable mechanisms from those datasets through quantitative methods, modeling, and theory that are directly connected to experimental design.
Because this is a team-research program, the structure of the investigative group is central. The FOA encourages applicants to cross disciplinary boundaries, linking experimental neuroscience with data science, statistics, engineering, and theoretical or computational neuroscience in a way that is genuinely interdependent. The ideal application reads like a single integrated program rather than several parallel projects: theory helps define what to measure and perturb, analysis methods are selected to answer the mechanistic questions posed, and experiments are designed to generate data that can constrain and test quantitative models. The cooperative agreement mechanism also signals that NIH program staff will have substantial involvement in oversight and coordination compared with a standard research grant, reflecting an emphasis on milestone-driven progress and programmatic alignment with broader BRAIN Initiative goals.
This specific FOA is positioned as a stepping-stone. The exploratory studies supported here are intended to develop experimental capabilities and the quantitative/theoretical frameworks needed for a later competition for larger-scale, multi-component Team-Research BRAIN Circuit Programs (U19). In practical terms, eTeamBCP projects should demonstrate feasibility, produce enabling methods or validated pipelines, and establish strong team integration around a compelling circuit question, setting applicants up to scale into a bigger, more complex program later.
Administratively, the opportunity was issued by the U.S. Department of Health and Human Services through NIH, with a creation date of May 17, 2018, and an original closing date of June 10, 2019. The listing indicates an expected number of awards of about five, and the award ceiling is shown as 0, which typically means the ceiling was not specified in the summary record and applicants must refer to the full FOA for budget limits and project period details. Eligibility is broad and includes many organization types: state, county, and local governments; special district governments; public and private institutions of higher education; independent school districts; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; and other entities as described in the FOA. The program is associated with multiple CFDA numbers (93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.313, 93.853, 93.865, 93.866, 93.867), reflecting its alignment across several NIH institutes, centers, or funding lines that participate in BRAIN-related activities.
Taken together, this grant opportunity targets ambitious, team-based, preclinical or basic neuroscience efforts that combine cutting-edge circuit interrogation tools with serious theory and analytics, all anchored to a clear question about how distributed neural circuits generate behavior or perception. The intent is to catalyze collaborations that can both invent and apply new methods for large-scale circuit analysis, producing the conceptual and technical foundation needed for a subsequent leap to larger, multi-component team programs.Apply for RFA NS 18 029
- The Department of Health and Human Services, National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.313, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on May 17, 2018.
- Applicants must submit their applications by Jun 10, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Funding Opportunity |
|---|
| BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Required) Apply for RFA NS 19 002 Funding Number: RFA NS 19 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed) Apply for RFA NS 19 003 Funding Number: RFA NS 19 003 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Back Pain Consortium (BACPAC) Research Program: Phase 2 Clinical Trials (UG3/UH3 Clinical Trial Required) Apply for RFA AR 19 029 Funding Number: RFA AR 19 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| HEAL Initiative: Coordinating Center to Support NIDA Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 1630) Initiative (U24 Clinical Trial Not Allowed) Apply for RFA DA 19 034 Funding Number: RFA DA 19 034 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $1,500,000 |
| Medical Rehabilitation Research Resource (P2C Clinical Trial Optional) Apply for RFA HD 20 004 Funding Number: RFA HD 20 004 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition for Adolescent Brain Cognitive Development (ABCD) Study - Data Analysis, Informatics and Resource Center (U24 Clinical Trial Not Allowed) Apply for RFA DA 20 003 Funding Number: RFA DA 20 003 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition for Adolescent Brain Cognitive Development (ABCD) Study - Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA DA 20 004 Funding Number: RFA DA 20 004 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition for Adolescent Brain Cognitive Development (ABCD) Study - Linked Research Project Sites (Collaborative U01 Clinical Trial Not Allowed) Apply for RFA DA 20 002 Funding Number: RFA DA 20 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Data Coordinating and Operations Center for the ECHO IDeA States Pediatric Clinical Trials Network - 2 (U24 - Clinical Trial Required -Infrastructure) Apply for RFA OD 19 025 Funding Number: RFA OD 19 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional) Apply for RFA AT 20 004 Funding Number: RFA AT 20 004 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trials Optional) Apply for RFA NS 20 029 Funding Number: RFA NS 20 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Martin Delaney Collaboratory for Pediatric HIV Cure Research (UM1 Clinical Trial Not Allowed) Apply for RFA AI 20 036 Funding Number: RFA AI 20 036 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $3,500,000 |
| BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed) Apply for RFA EB 20 002 Funding Number: RFA EB 20 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $250,000 |
| Emergency Awards: Automatic Detection and Tracing of SARS-CoV-2 (U01 Clinical Trial Not Allowed) Apply for RFA OD 20 014 Funding Number: RFA OD 20 014 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Emergency Awards RADx-RAD: Screening for COVID-19 by Electronic-Nose Technology (SCENT) (U18 Clinical Trial Not Allowed) Apply for RFA OD 20 017 Funding Number: RFA OD 20 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed) Apply for RFA NS 21 013 Funding Number: RFA NS 21 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Targeted BRAIN Circuits Planning Projects TargetedBCPP (R34 Clinical Trials Not Allowed) Apply for RFA NS 21 014 Funding Number: RFA NS 21 014 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $225,000 |
| Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03) Apply for PAR 16 348 Funding Number: PAR 16 348 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01) Apply for RFA MH 17 220 Funding Number: RFA MH 17 220 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Non-Invasive Neuromodulation - Mechanisms and Dose/Response Relationships for Targeted CNS Effects (R01) Apply for RFA MH 17 245 Funding Number: RFA MH 17 245 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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