Opportunity Information: Apply for RFA NS 17 022
This funding opportunity, titled "Data Management and Coordinating Center (DMCC) for the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRC) (U24)," is a National Institutes of Health (NIH) cooperative agreement designed to stand up a central hub that supports a broader network of ME/CFS Collaborative Research Centers. The main idea is that, alongside multiple research centers doing scientific and clinical work on ME/CFS, there needs to be a dedicated coordinating and data infrastructure center that makes the network function smoothly, consistently, and efficiently. The DMCC is meant to be that backbone, providing shared systems, standards, and coordination so that work happening at different sites can be integrated, compared, and leveraged across the network rather than remaining siloed.
The FOA emphasizes that the DMCC will focus on infrastructure and support for the individual ME/CFS CRCs and their activities. In practical terms, this means building and running the data management capabilities that allow centers to collect clinical and research data in a consistent way, store it securely, curate it so it is usable, and then enable appropriate analysis, mining, and sharing. Clinical data management is highlighted as a core function, with an explicit goal of making data collection efficient and high quality, which usually implies standardized data elements, harmonized forms and procedures, clear data dictionaries, quality control checks, and processes for timely data submission and cleaning. Beyond basic storage, the opportunity also calls out data mining and data sharing, pointing to a role for the DMCC in making the network's data findable and usable for broader scientific discovery while still meeting privacy, ethics, and regulatory requirements.
A key purpose of creating this DMCC is to strengthen the CRC network's ability to do three major kinds of work. First, the network is intended to facilitate collaborative basic and/or clinical research on ME/CFS, which implies cross-center alignment on measures, shared protocols where appropriate, and mechanisms to coordinate multi-site projects. Second, the CRCs are expected to conduct longitudinal studies of individuals with ME/CFS, both within each center and across centers, which increases the importance of consistent follow-up schedules, shared outcome measures, and the ability to merge or compare datasets over time. Third, the network aims to expand access to information related to ME/CFS for a wide audience that includes basic and clinical researchers, academic and practicing physicians, healthcare professionals, patients, and the general public. That third aim signals that the DMCC may also support outward-facing dissemination functions, such as maintaining a website or portal, distributing network updates, and providing resources that translate research outputs into accessible information, though the exact scope would be defined by the cooperative agreement and the network's governance.
This opportunity is issued by the U.S. Department of Health and Human Services through the NIH, and it is categorized as a discretionary grant using a cooperative agreement mechanism (U24). A cooperative agreement typically means the funding agency expects to have substantial involvement in the project, not just provide funds and step back. In a networked program like this, that generally translates into NIH program staff participating in coordination, setting expectations for milestones and deliverables, and helping align the DMCC's operations with the needs of the CRCs and the overall program goals.
The FOA lists a broad set of eligible applicants, including various levels of government (state, county, city/township), special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, other tribal organizations, public housing authorities/Indian housing authorities, nonprofit organizations (both with and without 501(c)(3) status, excluding higher education institutions in those categories), for-profit organizations other than small businesses, small businesses, and other entities as clarified in the full eligibility text. This wide eligibility suggests the NIH is primarily focused on finding an organization with the capability to run a sophisticated, compliant, and collaborative data and coordination operation, rather than limiting eligibility to one institutional type.
From the provided details, the funding opportunity number is RFA-NS-17-022, and it was created on January 27, 2017, with an original closing date of May 2, 2017. The award ceiling is listed as $750,000, and the FOA anticipated making one award, indicating a single DMCC would be selected to serve the entire CRC network. The listing includes multiple CFDA numbers (including 93.213, 93.233, 93.273, 93.279, 93.350, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.855, 93.856), reflecting the NIH's cataloging and potential institute or programmatic connections relevant to the initiative.
Overall, the opportunity is best understood as funding for the central operating and data engine of an ME/CFS research network. Rather than being primarily a discovery science award, it is structured to ensure that the clinical and research data generated by multiple ME/CFS Collaborative Research Centers are collected in a rigorous, standardized manner; managed securely and efficiently; and made usable for cross-site collaboration, longitudinal analysis, and broader data-driven advances. The DMCC is expected to make the network more than the sum of its parts by enabling coordinated multi-center work, improving data comparability, supporting responsible sharing and secondary use, and helping deliver ME/CFS-related information to both professional and public audiences.Apply for RFA NS 17 022
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Data Management and Coordinating Center (DMCC) for the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRC) (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.233, 93.273, 93.279, 93.350, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.855, 93.856.
- This funding opportunity was created on Jan 27, 2017.
- Applicants must submit their applications by May 02, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "Data Management and Coordinating Center (DMCC) for the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRC) (U24)."
What is the main purpose of the DMCC award?
The purpose is to stand up a central hub that provides the shared data infrastructure and coordination needed for the ME/CFS Collaborative Research Centers (CRCs) to operate as an integrated network rather than as separate, siloed sites.
What type of grant mechanism is being used?
This is an NIH cooperative agreement using the U24 mechanism.
What does a cooperative agreement (U24) imply about NIH involvement?
A cooperative agreement typically means NIH expects substantial involvement in the project. In this network context, that generally includes NIH program staff participating in coordination, setting expectations for milestones and deliverables, and helping align DMCC operations with CRC needs and overall program goals.
Which agency is offering this opportunity?
It is issued by the U.S. Department of Health and Human Services through the National Institutes of Health (NIH).
What problem is the DMCC intended to solve for the CRC network?
The DMCC is intended to provide the backbone systems, standards, and coordinating functions that allow data and activities across multiple ME/CFS CRCs to be consistent, comparable, and usable for cross-site collaboration and longitudinal research.
Is this award mainly for conducting discovery research on ME/CFS?
No. Based on the description provided, it is primarily structured to fund infrastructure and support functions (data management, coordination, and enabling collaboration) for the CRC network, rather than serving as a stand-alone discovery science award.
What are the DMCC's core responsibilities related to data?
The DMCC is expected to build and run data management capabilities that help CRCs collect data consistently, store it securely, curate it for usability, and enable appropriate analysis, mining, and sharing while meeting privacy, ethics, and regulatory requirements.
Why is clinical data management emphasized in this FOA?
Clinical data management is highlighted as a core function with an explicit goal of making data collection efficient and high quality across CRCs. That implies standardization and quality processes that support reliable, comparable multi-site clinical and research datasets.
What kinds of practices are implied for standardized, high-quality data collection?
The description points to common elements such as standardized data elements, harmonized forms and procedures, clear data dictionaries, quality control checks, and processes for timely data submission and data cleaning.
Does the DMCC have a role in data mining?
Yes. The opportunity calls out data mining as part of the DMCC role, meaning the DMCC should help make network data usable for discovery and analysis across the program, consistent with required protections and governance.
Does the DMCC have a role in data sharing?
Yes. Data sharing is explicitly noted, with an emphasis on making data findable and usable for broader scientific discovery while still meeting privacy, ethics, and regulatory requirements.
How does the DMCC support collaboration across research centers?
By providing shared systems and standards (and coordination mechanisms), the DMCC enables cross-center alignment on measures, helps support shared protocols where appropriate, and facilitates multi-site projects and network-wide integration of data and activities.
How does this opportunity relate to longitudinal studies of people with ME/CFS?
The CRC network is expected to conduct longitudinal studies within and across centers. This increases the need for consistent follow-up schedules, shared outcome measures, and the ability to merge or compare datasets over time, which are functions supported by the DMCC infrastructure and coordination.
Who is the intended audience for information expanded by the network?
The program aims to expand access to ME/CFS-related information for basic and clinical researchers, academic and practicing physicians, healthcare professionals, patients, and the general public.
Does the DMCC have outward-facing dissemination responsibilities?
The third program aim signals that the DMCC may support dissemination functions such as maintaining a website or portal, distributing network updates, and providing accessible resources. The exact scope would be defined through the cooperative agreement and network governance.
Who is eligible to apply?
The FOA lists broad eligibility, including state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (with or without 501(c)(3) status, excluding higher education institutions in those categories); for-profit organizations other than small businesses; small businesses; and other entities as clarified in the full eligibility text.
Why is eligibility so broad for this DMCC?
The wide eligibility suggests NIH is prioritizing organizational capability to run a sophisticated, compliant, collaborative data and coordination operation, rather than restricting eligibility to a narrow type of institution.
What is the funding opportunity number?
The funding opportunity number is RFA-NS-17-022.
When was this opportunity created and when did it close?
It was created on January 27, 2017, and the original closing date was May 2, 2017.
What is the award ceiling for this opportunity?
The award ceiling is listed as $750,000.
How many awards were anticipated?
The FOA anticipated making one award, indicating that a single DMCC would be selected to serve the entire CRC network.
What does it mean that this is a discretionary grant?
It is categorized as a discretionary grant, meaning it is awarded through a competitive process and is not an entitlement or formula-based funding stream.
Which CFDA numbers are associated with this listing?
The listing includes multiple CFDA numbers: 93.213, 93.233, 93.273, 93.279, 93.350, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.855, 93.856.
How should this opportunity be understood in the context of the ME/CFS CRC program?
It is best understood as funding for the central operating and data engine of the ME/CFS CRC network: establishing rigorous, standardized data collection; secure and efficient data management; support for cross-site collaboration and longitudinal analysis; responsible sharing and secondary use; and helping deliver ME/CFS-related information to professional and public audiences.
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